Every action in the brain - whether catching a ball, calming a panic attack, or waking from anaesthesia - starts at the synapse. In physiology, you’ve already met the major neurotransmitters: GABA, glutamate, dopamine, serotonin, acetylcholine, and noradrenaline.
Now it’s time to see these in clinical action. If you haven't already read it, go back and check out the Neurotransmitters 101 post, it will help it all make sense.
Many drugs and substances - from prescription medications to recreational drugs - alter the brain’s electrochemical balance. They dial neurotransmitter signalling up or down, leading to effects that are therapeutic, recreational, harmful, or all three. Understanding how they work builds your clinical intuition - and helps you spot mechanisms behind both therapeutic effects and side effects.
We’ll explore how each class works, what effects they trigger, and where they act in the neural circuit. Consider this your pharmacological map of the CNS - designed for clarity, clinical context, and curiosity.