BIG PRE-EXAM QUIZ

 Here's another big one in the lead up to exams. 
EMQs, BOFs, Case Based MCQs, from all the themes. 

Enjoy! 

Autoimmune quiz

 In case you missed the Autoimmune quiz on the big TV this week :) 

Enjoy! 

Quiz TV week 3

 This week the TV screens are full of autoimmune questions. 

Last week's quiz TV is live for revision :) 

Rheumatoid Arthritis: Unravelling the Pathophysiology 🧬

👋 Let’s dive into the fascinating (and complex) world of Rheumatoid Arthritis (RA)—a classic autoimmune disorder that’s important to understand for future clinical practice. 🩺📚

As always, understanding the pathophysiology helps to make it all make sense. 

Antiphospholipid syndrome: A prothrombotic puzzle

Pathophysiology of antiphospholipid syndrome

Antiphospholipid syndrome (APS) is an autoimmune disorder characterised by the presence of antiphospholipid antibodies (aPL), which target phospholipid-binding proteins involved in coagulation. These antibodies disrupt normal endothelial function, leading to hypercoagulability and an increased risk of thrombosis.

Understanding the pathophysiology of systemic lupus erythematosus (SLE)

 Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterised by multisystem involvement and a complex interplay of genetic, environmental, and immunological factors. It primarily affects young women and can manifest with diverse clinical symptoms, ranging from mild cutaneous involvement to life-threatening organ damage. Understanding its pathophysiology is crucial for developing targeted therapies and improving patient outcomes.

Immune Tolerance & The Development of Autoimmunity

The immune system functions as a highly selective defence network, recognising foreign pathogens while preserving self-tolerance to avoid attacking the body’s own tissues. This balance is essential for immune homeostasis—but when tolerance mechanisms break down, autoimmune diseases develop, causing chronic inflammation and tissue destruction.

Understanding how immune tolerance is established, maintained, and eventually fails provides critical insight into the pathophysiology of autoimmunity.