QUIZ: Acute viral hepatitis

🧪 Quiz: Acute Viral Hepatitis

These Best-of-Five questions will test your understanding of the pathophysiology, transmission, and laboratory features of acute viral hepatitis. Ready to apply what you've learned? Like all the quizzes, you can have a try and check your answers anonymously, then reset the quiz to try again later !

1. Sam, a 25-year-old teacher, presents with fatigue, jaundice, dark urine, and pale stools one week after returning from a surfing trip in Central America. He reports eating seafood from local beach vendors. Blood tests show:
ALT: 950 U/L (normal <40 U/L)
AST: 780 U/L (normal <40 U/L)

Which hepatitis virus is the most likely cause of his symptoms?
A. Hepatitis B from perinatal transmission
B. Hepatitis C from needle sharing
C. Hepatitis D from co-infection with HBV
D. Hepatitis A from contaminated food
E. Hepatitis E from a healthcare setting

2. A 32-year-old man presents with right upper quadrant pain and fatigue three weeks after an unprotected sexual encounter. Labs show elevated ALT, positive HBsAg, HBeAg, and anti-HBc IgM.

What is the main mechanism of liver cell injury in this setting?
A. Direct cytopathic effect of HBV
B. Immune-mediated apoptosis by cytotoxic T cells
C. Viral inhibition of bile acid synthesis
D. Hepatotoxic viral protein production
E. Endotoxin-mediated inflammation

3. A 29-year-old woman with no symptoms is found to have mildly elevated ALT and AST on routine blood tests. Serology reveals anti-HCV antibodies and HCV RNA positivity.

What best explains the high chronicity rate of hepatitis C?
A. High viral mutation rate impairs immune recognition
B. Integration of HCV into the host genome
C. Absence of natural killer cell response
D. Direct hepatocyte cytotoxicity
E. Pre-existing liver fibrosis at exposure

4. Which of the following laboratory findings most strongly suggests acute hepatocellular injury due to viral hepatitis?
A. ALP > ALT, elevated GGT
B. ALT > AST, levels >10× normal
C. Normal transaminases, elevated bilirubin
D. Thrombocytopenia with mildly elevated ALT
E. ALP elevation with normal bilirubin

5. Which of the following events is most responsible for hepatocyte destruction during acute viral hepatitis?
A. Viral entry and replication within hepatocytes
B. Obstruction of intrahepatic bile ducts
C. Interferon-induced suppression of viral RNA
D. Kupffer cell–mediated phagocytosis
E. Adaptive immune response by CD8+ T cells

Want to try more quizzes?

• 📝 Browse all quiz questions →